Professional & One-stop Lentivirus Packaging Solutions
The lentivirus vector, which is derived from HIV-1 and engineered to contain the vesicular stomatitis virus glycoprotein (VSVG) envelope, represents a highly powerful gene therapy vector. As a modified retrovirus, its virulence genes have been replaced with an exogenous target gene. This novel design empowers the vector to integrate the exogenous gene efficiently into the host chromosome, thus enabling stable and long-lasting expression of the introduced gene.
Furthermore, the lentivirus vector demonstrates versatile infection capabilities, effectively targeting a wide array of cell types. These include neurons, hepatocytes, cardiomyocytes, tumor cells, endothelial cells, stem cells, and many others. This broad tropism ensures robust and reliable gene transduction, rendering the lentivirus vector an indispensable tool for advanced gene therapy applications. Genzera offers a one-stop service, covering everything from gene synthesis to lentivirus packaging. It provides high-quality lentiviral packaging plasmids that are suitable for both cell infection and in vivo animal experiments.
Key Features
- Broad Infection Spectrum: The lentivirus vector can efficiently infect both dividing and non – dividing cells, including primary cells.
- Stable Expression: Once it infects the host cell, the lentivirus integrates the exogenous gene into the host cell’s genome. This allows for continuous and stable expression throughout cell division.
- High Safety Profile: The lentivirus is a recombinant replication – defective strain. This ensures operational safety since it cannot replicate autonomously.
- Resistance to Gene Silencing: The integrated exogenous gene fragments are resistant to gene silencing.
- Large Payload Capacity: It is capable of carrying relatively large exogenous fragments, with a capacity of up to 4.8 kb.
Selection Guide
| Scale | Package | Turnaround time** | Price |
| Medium | Customized Over-expression Lentivirus (gene ≤ 3kb), Deliverables: ≥ 2×108 TU/ml, 200 μl | 20-25 business days | Quote |
| Customized RNAi Lentivirus (single target), Deliverables: ≥ 2×108 TU/ml, 200 μl | 20-25 business days | Quote | |
| Customized RNAi Lentivirus (Design 3 targets, 1 target with guaranteed effect), Deliverables: ≥ 2×108 TU/ml, 200 μl | 20-25 business days | Quote | |
| Customized sgRNA Lentivirus (single target), Deliverables: ≥ 2×108 TU/ml, 200 μl | 20-25 business days | Quote | |
| Customized sgRNA Lentivirus(three targets), Deliverables: ≥ 2×108 TU/ml, 200 μl | 20-25 business days | Quote | |
| Large | Customized Over-expression Lentivirus (gene ≤ 3kb), Deliverables: ≥ 109 TU/ml, 200 μl | 25-30 business days | Quote |
| Customized RNAi Lentivirus, Deliverables: ≥ 109 TU/ml, 200 μl | 25-30 business days | Quote | |
| Customized sgRNA Lentivirus (single target), Deliverables: ≥ 109 TU/ml, 200 μl | 25-30 business days | Quote |
* Download the list of lentiviral packaging plasmids;
** Turnaround time includes plasmid construction and preparation.
Deliverables
| Custom Lentivirus, delivered to specification: Medium Scale: ≥ 108 TU/ml, 5 x 200 μl Large Scale: ≥ 109 TU/ml, 5 x 200 μl |
| Free: Control virus Medium Scale: > 108 TU/ml, 5 x 200 μl Large Scale: > 109 TU/ml, 5 x 200 μl |
| Polybrene, 10 mg/ml, 1 x 200 μl (Free) |
| Dry ice/-80 ° C, avoid repeated freezing and thawing |
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