Background

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.

Images

	Western blotting analysis using anti-Integrin subunit alpha 2 antibody (Cat#71145). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-Integrin subunit alpha 2 antibody (Cat#71145, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716).
	Western blotting analysis using anti-integrin subunit alpha 2 antibody (Cat#71145). Integrin subunit alpha 2 expression in wild type (WT) and integrin subunit alpha 2 (ITGA2) knockout (KO) HSHC cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with anti-integrin subunit alpha 2 antibody (Cat#71145, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716).
	Flow cytometric analysis of Integrin subunit alpha 2 expression in HepG2 cells using anti-Integrin subunit alpha 2 antibody (Cat# 71145, 1:2,000). Green, isotype control; red, Integrin subunit alpha 2.