Background

This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene.

Images

	Western blotting analysis using anti-solute carrier family 25 member 12 antibody (Cat#62662). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-solute carrier family 25 member 12 antibody (Cat#62662, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226).
	Western blotting analysis using anti-Solute carrier family 25 member 12 antibody (Cat#62662). Solute carrier family 25 member 12 expression in wild type (WT) and Solute carrier family 25 member 12 shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates . β-Tubulin serves as a loading control. The blot was incubated with anti-Solute carrier family 25 member 12 antibody (Cat#62662, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716).
	Flow cytometric analysis of Solute carrier family 25 member 12 expression in C2C12 cells using anti-Solute carrier family 25 member 12 antibody (Cat#62662, 1:2,000). Green, isotype control; red, Solute carrier family 25 member 12.

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